Pharmaceutical Multi-effect Distilled Water Generator(WFI System)
Pharmaceutical multi-effect distilled water generator (WFI system) is a GMP-compliant injection water production equipment and high-efficiency distilled water machine.
This distilled water generator is a GMP-certified purified water production system. Adopting multi-effect distillation technology, it enables continuous production of injection-grade pure water (compliant with ChP/USP/EP standards) and is widely applied in biopharmaceuticals, injection manufacturing, and sterile preparations.
Core advantages: Over 30% energy savings, modular design, and automatic control system.
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Technical Principle of distilled water generator
Using falling film evaporation (raw material water evaporates in a film on the wall of the efferent body), compared with boiling evaporation, can reduce the entrainment of fog and ensure that the produced water is pyrogen free.
Multi-effect series thermal cycling
Based on the thermodynamic characteristics that the boiling point decreases with the decrease of pressure, multiple evaporators (effector) are connected in series, and the secondary steam of the former effect is used as the heat source of the latter effect to form energy cascade utilization.
Steam flow
Flow direction
Key technological innovation points
| Technical module | Principle statement | Pharmaceutical application value |
| Intereffect pressure control | The pressure difference between effects (usually ≥0.1MPa) is maintained through the vacuum system to ensure the automatic flow of steam to the cryogenic effect | Reduce the mechanical pump energy consumption, prolong the equipment life |
| TOC degradation design | A delay chamber is set in the first effect high temperature section (≥105℃) to decompose organic matter | Meet the requirements of pharmacopeia for TOC≤500ppb |
| Condensation purification | Double tube plate condenser + spiral spoiler is used to prevent leakage and pollution of cooling medium | Ensure that the endotoxin of water production is ≤0.25EU/mL |
Core Function of distilled water generator
Multi-effect energy saving
6-effect distillation design, energy efficiency 40% (compared with single effect)
Aseptic guarantee
Built-in 0.22μm hydrophobic filter to ensure that the water for injection is pyrogen free
Intelligent monitoring
real-time monitoring of TOC/ conductivity / temperature, support data export (in line with FDA audit trail requirements)
CIP/SIP
Fully automated in-place cleaning/sterilization process to reduce the risk of cross-contamination
Competitive Advantage
VS Traditional distiller
VS Reverse osmosis equipment
Product Configuration of distilled water generator
| Main component | Technical parameter | Approval standards |
| Evaporator material | 316L stainless steel/electropolished finish | GMP Annex 1 |
| Condensing system | Double tubesheet heat exchanger | ASME BPE certification |
| Control system | PLC+ touch screen (data recording/alarm tracing) | 21 CFR Part 11 Compliance |
| Water production capacity | 50-6000L/h (customizable) | Pharmacopoeia standard for purified water |
Product Model-WFI Systems
| No. | Model | Capacity |
| 1 | MOLWFI-50L | 50L/H |
| 2 | MOLWFI-100L | 100L/H |
| 3 | MOLWFI-300L | 300L/H |
| 4 | MOLWFI-500L | 500L/H |
| 5 | MOLWFI-1000L | 1000L/H |
| …… | ……. | …… |
| 6 | MOLWFI-10000L | 10000L/H |
Project Case
GMP certification | 50% energy saving | Water for injection
Multi-effect distillation(WFI) generator through the FDA/GMP certification, the production of water in line with pharmacopeia standards, provide 50-5000L/h custom solution, support CIP/SIP cleaning verification.
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