750LPH Pharmaceutical Purified Water System Exported to Jordan
A pharmaceutical enterprise in Jordan contacted Molewater’s engineers to meet local GMP regulations and international pharmacopoeial standards, and address issues such as stable water quality, continuous water production, and multi-process water demand of the water supply system. After in-depth understanding of its water usage process, capacity requirements, water quality standards, and local climate conditions, the engineers customized a 750L/h pharmaceutical purified water system that not only meets the full-process production water requirements of APIs and oral preparations but also adapts to the local operation and maintenance environment.
Project challenges
High water quality compliance requirements: It needs to meet both local Jordanian GMP regulations and USP (United States Pharmacopeia) standards. The produced water must achieve “conductivity ≤1.3μS/cm (25℃), total organic carbon ≤500ppb, microorganisms <100CFU/ml, and no pyrogen contamination”.
Difficulty in coordinating multi-process water usage: Production involves multiple water usage points such as API batching (purified water), oral preparation granulation (purified water), and equipment cleaning (pure steam), with concerns about cross-contamination risks.
High operation and maintenance costs and pressure: Local operation and maintenance personnel have limited professionalism, but the equipment requires special personnel to monitor water quality at high frequency. Moreover, the reverse osmosis membrane is prone to clogging due to the local high-hardness raw water, resulting in high annual operation and maintenance costs
Process flow
Mole Water Treatment has created a customized pharmaceutical purified water system for the pharmaceutical factory. All components are optimally designed according to customer needs, balancing durability and high performance. Each core unit of the system operates synergistically to continuously output stable purified water. The specific process is as follows:
Pretreatment unit: Adopting multi-stage pretreatment filtration, including multi-media filter to remove suspended solids and turbidity in water, activated carbon filter to adsorb residual chlorine and organic pollutants, water softener to reduce inlet water hardness and prevent scaling risks, plus a 5-micron precision filter for terminal pretreatment. This unit can extend the service life of core components.
Reverse osmosis unit: Configured with double-stage reverse osmosis + EDI to maximize pollutant removal efficiency. Double-stage reverse osmosis removes over 99% of ions and organic substances, and EDI further increases water resistivity to above 15MΩ・cm. Mole Water Treatment selects low-energy consumption, high-flux, and wear-resistant reverse osmosis membranes, paired with energy-saving high-pressure pumps with overpressure protection functions, which can flexibly adapt to power fluctuation scenarios.
Sterilization and transportation unit: Adopting 254nm UV sterilization method, equipped with a thermal disinfection pump and electric heater to perform high-temperature disinfection on reverse osmosis produced water and transportation pipelines. Finally, the produced water meets the pharmacopoeial purified water standard of bacteria count <100 CFU/mL and is transported to various water usage points
Project achievements
Stable and compliant water quality: The produced water continuously meets USP and local GMP standards. Third-party testing shows that conductivity, TOC, microorganisms, and other indicators are stably within the qualified range, and the product has passed the certification of the Jordanian drug regulatory authority.
Efficient adaptation to multiple scenarios: The quality-separated water supply pipeline covers 3 preparation production lines and 2 cleaning stations, with no water supply interruption during peak water usage, and the product batch stability is significantly improved.
Controllable operating costs: The system has a high degree of automation and only requires daily remote inspections. The pretreatment unit effectively extends the service life of the reverse osmosis membrane, and the annual operation and maintenance cost is as low as 30,000 Jordanian Dinars compared with peers.
Empowering the local operation and maintenance team: Mole provides remote operation training and after-sales guidance to help local staff master daily maintenance and troubleshooting skills, reducing the cost of consulting technical personnel